Average Physician Salary in Missouri

Physicians diagnose and treat illnesses, injuries, and other health conditions. They are the highest-paid professionals in the healthcare system, combining years of intensive medical training with clinical judgment that directly impacts patient outcomes. The field spans two main pathways — primary care (family medicine, internal medicine, pediatrics) and specialty medicine — with specialists earning substantially more. The national median annual salary exceeds $239,000, but top earners in procedural specialties such as orthopedic surgery, cardiovascular surgery, and neurosurgery regularly surpass $600,000.

In Missouri, physicians earn an average of $218,457 per year as of 2026, with salaries ranging from $144,733 for entry-level roles to $323,095 for the most experienced professionals — +8.7% below the national average. Pay is influenced most by specialty — surgical subspecialties earn 2–3× more than primary care, practice setting — private practice ownership often maximizes income vs. employed positions, and the specific metro area within Missouri.