Average Nurse Practitioner Salary in Missouri

Nurse practitioners (NPs) are advanced practice registered nurses who provide high-level patient care including diagnosing conditions, prescribing medications, and managing chronic diseases. They hold full practice authority in over 25 states, meaning they can practice independently without physician oversight — making them increasingly central to closing primary care gaps in the US. NPs specialize across family practice, pediatrics, adult-gerontology, psychiatric-mental health, women's health, and acute care, with psychiatric NPs seeing the fastest demand growth.

In Missouri, nurse practitioners earn an average of $115,974 per year as of 2026, with salaries ranging from $74,483 for entry-level roles to $169,575 for the most experienced professionals — +8.1% below the national average. Pay is influenced most by specialty — psychiatric and acute care nps earn more than family practice, full practice authority state — independent practice often enables higher compensation, and the specific metro area within Missouri.